RIPK1-IN-13

CAT: 0804-HY-146757Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146757Size:1 Each
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Description
RIPK1-IN-13 (Compound 8) is a potent inhibitor of RIPK1 with an IC50 value of 1139 nM. RIPK1-IN-13 blocks the activation of the necroptosis pathway via the inhibition of RIPK1. RIPK1-IN-13 has the potential for the research of inflammation diseases[1].
CAS Number
[1574547-67-3]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk1-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2(NC(N(C2=O)CC3=CC(Cl)=CC=C3)=O)CC1)C4=CC=CC=C4
Molecular Formula
C21H20ClN3O3
Molecular Weight
397.85
References & Citations
[1]Niu A, et al. Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors. Bioorg Med Chem. 2022 Apr 1;59:116686.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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