JWZ-7-7-Neg1

• UNSPSC Description:

  JWZ-7-7-Neg1 is a transcriptional chemical inducers of proximity (TCIP) with negative chemical control. JWZ-7-7-Neg1 reduces the ability to bind to BRD4 or BCL6, so it has less cytotoxicity to DLBCL cells, in compared with JWZ-7-7[1].

• Target Antigen:

  BCL6; Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Immunology/Inflammation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/jwz-7-7-neg1.html

• Smiles:

  CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](CC(NCCCCCCCNC(C4CCN(C5=NC=C(Cl)C(NC6=CC(OC)=C(N(C(C(OCC(NC)=O)=C7)=O)C)C7=C6)=N5)CC4)=O)=O)C8=NN=C(C)N28

• Molecular Weight:

  1026.04

• References & Citations:

  [1]Crabtree GR, et al., Compositions, systems, and methods for modulating a target gene. WO2023215311.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3008612-30-1