JWZ-7-7-Neg1

JWZ-7-7-Neg1

• CAS Number: 3008612-30-1
• UNSPSC Description: JWZ-7-7-Neg1 is a transcriptional chemical inducers of proximity (TCIP) with negative chemical control. JWZ-7-7-Neg1 reduces the ability to bind to BRD4 or BCL6, so it has less cytotoxicity to DLBCL cells, in compared with JWZ-7-7[1].
• Target Antigen: BCL6; Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics;Immunology/Inflammation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/jwz-7-7-neg1.html
• Smiles: CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](CC(NCCCCCCCNC(C4CCN(C5=NC=C(Cl)C(NC6=CC(OC)=C(N(C(C(OCC(NC)=O)=C7)=O)C)C7=C6)=N5)CC4)=O)=O)C8=NN=C(C)N28
• Molecular Weight: 1026.04
• References & Citations: [1]Crabtree GR, et al., Compositions, systems, and methods for modulating a target gene. WO2023215311.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported