HDAC6-IN-5

HDAC6-IN-5

• CAS Number: 2413603-15-1
• UNSPSC Description: HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].
• Target Antigen: Amyloid-β; Cholinesterase (ChE); HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hdac6-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO
• Molecular Weight: 408.25
• References & Citations: [1]Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported