HDAC6-IN-5

CAT: 0931-T62046-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T62046-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2413603-15-1

Target

Others, Beta Amyloid, Cholinesterase (ChE), HDAC

Related Pathways

DNA Damage/DNA Repair, Neuroscience, Chromatin/Epigenetic, Others

Bioactivity

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50 = 0.025 μM) that inhibits Aβ 1-42 self-aggregation and AChE with IC50 values of 3.0 and 0.72 μM, respectively. Additionally, HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.

Smiles

N(C=1C2=C(N=C3C1C=CC=C3)C=CC(Br)=C2)C4=CC=C(C(NO)=O)C=C4

Molecular Formula

C20H14BrN3O2

Molecular Weight

408.25

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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