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HDAC6 degrader-5

CAT: 0931-T204412-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204412-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
HDAC, Interleukin, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Immunology/Inflammation, Chromatin/Epigenetic
Bioactivity
HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.
Smiles
CCCC1=CC(=NN1CC2=CC=C(C=C2)C(=O)NO)C(=O)NC3=CC=CC=C3
Molecular Formula
C21H22N4O3
Molecular Weight
378.424
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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