LSD1-IN-20

• Description:

  LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase; Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-20.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC2=C (C (NC3CCN (CC3) CC4=CC=CC=C4) =NC (NCCCN (C) C) =N2) C=C1OC

• Molecular Formula:

  C27H38N6O2

• Molecular Weight:

  478.63

• References & Citations:

  [1]Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1

• CAS Number:

  1239589-91-3