CDK-IN-2

• Description :

  CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I[1][2].

• Product Name Alternative :

  CDK inhibitor II

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/CDK-IN-2.html

• Concentration :

  10mM

• Purity :

  99.27

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  FC1=CC(C2=CC(NC([C@H]3CNCCC3)=O)=NC=C2Cl)=C(C=C1)OC

• Molecular Formula :

  C18H19ClFN3O2

• Molecular Weight :

  363.81

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.|[2]Li H, et al. Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse. Cell Mol Life Sci. 2022 Aug 5;79 (8) :467.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK9

• CAS Number :

  [1269815-17-9]