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CDK4/6-IN-13

CAT: 0804-HY-146214Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146214Size:1 Each
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Description
As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6.
CAS Number
1908454-70-5
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-13.html
Solubility
10 mM in DMSO
Smiles
CC(C1=C(C2=CN=C(N=C2N3C=C(N=C13)C(C)C)NC4=CC=C(C=C4)N5CCNCC5)C)=O
Molecular Formula
C25H29N7O
Molecular Weight
443.54
References & Citations
[1]Shi C, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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