CDK4/6-IN-13

• UNSPSC Description:

  As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6.

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk4-6-in-13.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1=C(C2=CN=C(N=C2N3C=C(N=C13)C(C)C)NC4=CC=C(C=C4)N5CCNCC5)C)=O

• Molecular Weight:

  443.54

• References & Citations:

  [1]Shi C,et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1908454-70-5