CDK4/6-IN-13

CDK4/6-IN-13

• CAS Number: 1908454-70-5
• UNSPSC Description: As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6.
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk4-6-in-13.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C1=C(C2=CN=C(N=C2N3C=C(N=C13)C(C)C)NC4=CC=C(C=C4)N5CCNCC5)C)=O
• Molecular Weight: 443.54
• References & Citations: [1]Shi C,et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported