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INOS/PGE2-IN-1

CAT: 0804-HY-146167Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146167Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INOS/PGE2-IN-1 (compound 4a), an iNOS/PGE2 inhibitor, is a potent anti-inflammatory agent. iNOS/PGE2-IN-1 can inhibit LPS-induced NO production. iNOS/PGE2-IN-1 possesses low ulcerogenic liabilities[1].
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/inos-pge2-in-1.html
Solubility
10 mM in DMSO
Smiles
N/C(C1=CC=CC=C1)=N\OC(CC2=C(N(C3=C2C=C(OC)C=C3)C(C4=CC=C(Cl)C=C4)=O)C)=O
Molecular Formula
C26H22ClN3O4
Molecular Weight
475.92
References & Citations
[1]Mohamed MFA, et, al. Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. Bioorg Chem. 2020 Dec;105:104439.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS

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