iNOS/PGE2-IN-1

• UNSPSC Description:

  iNOS/PGE2-IN-1 (compound 4a), an iNOS/PGE2 inhibitor, is a potent anti-inflammatory agent. iNOS/PGE2-IN-1 can inhibit LPS-induced NO production. iNOS/PGE2-IN-1 possesses low ulcerogenic liabilities[1].

• Target Antigen:

  NO Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/inos-pge2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N/C(C1=CC=CC=C1)=N\OC(CC2=C(N(C3=C2C=C(OC)C=C3)C(C4=CC=C(Cl)C=C4)=O)C)=O

• Molecular Weight:

  475.92

• References & Citations:

  [1]Mohamed MFA, et, al. Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors. Bioorg Chem. 2020 Dec;105:104439.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported