INOs-IN-3

• Description:

  INOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 μM) . iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research[1].

• UNSPSC:

  12352005

• Target:

  NO Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/inos-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC2=CC=CC(OS(=O)(C3=CC=CC4=C(N(C)C)C=CC=C43)=O)=C2N1CCC5=CC=CC=C5

• Molecular Formula:

  C27H24N2O5S

• Molecular Weight:

  488.55

• References & Citations:

  [1]Li Tang, et al. Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI) . Bioorg Med Chem. 2020 Nov 1;28 (21) :115733.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2241674-94-0