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5-trans-PGE2

CAT: 0804-HY-135023-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135023-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase) . This process is involved in the growth and development of breast cancer[1].
CAS Number
36150-00-2
Product Name Alternative
5-trans Prostaglandin E2
UNSPSC
12352211
Hazard Statement
H302-H360
Target
Cytochrome P450; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-trans-pge2.html
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C/CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.47
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Richards JA, et al. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J Clin Endocrinol Metab. 2003 Jun;88 (6) :2810-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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