INOs-IN-6

• Description:

  INOs-IN-6 is an anti-inflammatory agent. iNOs-IN-6 inhibits NF-κB, iNOS, and MAPK expression (IC50: 0.2-0.62 μM) . iNOs-IN-6 reduces IL-6, TNF-α, and IL-1β pro-inflammatory mediators levels (IC50: 0.4-0.69 μM) [1].

• UNSPSC:

  12352005

• Target:

  Interleukin Related; NF-κB; NO Synthase; p38 MAPK

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

• Field of Research:

  Inflammation/Immunology

• Smiles:

  ClC1=CC=C (NC (C2=C (C) NC (NC2C3=CC4=C (C=CC=C4) S3) =O) =O) C=C1

• Molecular Formula:

  C20H16ClN3O2S

• Molecular Weight:

  397.88

• References & Citations:

  [1]Ahmed R. Ali, et al. Design, synthesis, and biological evaluation of new tetrahydropyrimidine derivatives as multitarget anti-inflammatory agents. European Journal of Medicinal Chemistry Reports. Volume 13, April 2025, 100259

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported