PI3K/HDAC-IN-3

PI3K/HDAC-IN-3

• CAS Number: 3006905-22-9
• UNSPSC Description: PI3K/HDAC-IN-3 (36) is a PI3K and HDAC dual inhibitor, with IC50 values of 0.23 nM and 172 nM for PI3Kα and HDAC1, respectively. PI3K/HDAC-IN-3 (36) suppresses AKT phosphorylation and increased H3 acetylation in MV4-11 cells. PI3K/HDAC-IN-3 (36) exhibits significant and dose-dependent anticancer efficacy in a MV4-11 xenograft model[1].
• Target Antigen: HDAC; PI3K
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-hdac-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C2C(C(OCCCCCCC(NC3=C(C=CC=C3)N)=O)=CC(C4=CC(NS(C5=CC=C(F)C=C5F)(=O)=O)=C(OC)N=C4)=C2)=NC=N1
• Molecular Weight: 676.73
• References & Citations: [1]Kehui Zhang, et al. Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Nov 30:264:116015.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported