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EGFR-IN-58

CAT: 0804-HY-146154Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146154Size:1 Each
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Description
EGFR-IN-58 (Compound 4a) is a potent, ATP-competitive, and selective EGFR inhibitor. EGFR-IN-58 shows potent cytotoxicity against melanoma, colon, and blood cancers[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-58.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=CN=C3NC4=CC5=C(N(C=C5)CC6=CC(F)=CC=C6)C=C4)=O
Molecular Formula
C31H30FN7O
Molecular Weight
535.61
References & Citations
[1]Ahmed Karam Farag, et al. Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitors. Bioorg Chem. 2022 Sep;126:105918.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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