Products for Research Use Only
RegisterLogin

PI3K-IN-58

CAT: 0931-T207435-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T207435-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
3067572-78-2
Target
Apoptosis, Bcl-2 Family, PI3K
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.
Smiles
C(=C/C(NCCO)=O)\C=1SC2=C(N=C(N=C2C1)C3=C4C(=CC=C3)NN=C4)N5CCOCC5
Molecular Formula
C22H22N6O3S
Molecular Weight
450.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T39542PI3Kδ-IN-8
T212311-01PI3Kδ-IN-25
T209704-01PI3Kδ-IN-20
T209367-01PI3K-IN-52
T206876-01PI3K-IN-56
T87164-01PI3Kα-IN-22
T87161-01PI3Kα-IN-17
T87158-01PI3Kα-IN-1
T63682-01PI3K-IN-2
T12462-01PI3Kδ-IN-1

Alternative Products

CatalogName
HY-172886PI3K-IN-58
YP-W200332-01Bovine PI3K (PI3K) ELISA Kit
YP-W63206-01Chicken PI3K (PI3K) ELISA Kit
abx236423PI3K P87 (PI3K p87) Antibody
abx037680-01Alpha (PI3K P85) (PI3K p85) Antibody
BA8725-1PI3K-IN-22
BA8769-10PI3Kδ-IN-5
BA8757-10PI3K-IN-36
BA8738-10PI3K-IN-30
BA8768-25PI3Kδ-IN-15

Popular Products