DASA-58

• Description:

  DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Pyruvate Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/DASA-58.html

• Concentration:

  10mM

• Purity:

  99.67

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  NC1=CC=CC(S(=O)(N2CCN(S(=O)(C3=CC=C(OCCO4)C4=C3)=O)CCC2)=O)=C1

• Molecular Formula:

  C19H23N3O6S2

• Molecular Weight:

  453.53

• Precautions:

  H302

• References & Citations:

  [1]Fadi Almouhanna, et al. Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells. Cancer Metab. 2021 Jan 22;9 (1) :5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1203494-49-8]