JHU-58

• Description:

  JHU-58 is a peptidomimetic agonist targeting mouse MRGPRC11 and rat MRGPRC receptors. JHU-58 demonstrates analgesic effects in mouse models of neuropathic pain. JHU-58 is promising for research of neuropathic pain[1].

• UNSPSC:

  12352005

• Target:

  Mas-related G-protein-coupled Receptor (MRGPR)

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Smiles:

  NC([C@H](CC1=CC=CC=C1)NC([C@H](N)CC2=CC=C(C=C2)NC(N)=N)=O)=O

• Molecular Formula:

  C19H24N6O2

• Molecular Weight:

  368.43

• References & Citations:

  [1]Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62 (18) :8631-8641.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1632140-61-4]