TRK-IN-19

• Description :

  TRK-IN-19 (Compound I-10) is a potent inhibitor of TRK (TRKA IC50 = 1.1 nM, TRKAG595R IC50 = 5.3 nM) . TRK-IN-19 has the potential for the research of cancer diseases[1].

• UNSPSC :

  12352005

• Target :

  Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/trk-in-19.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1CCC(CC1)NC(C2=C3N=C(C=CN3N=C2)N(CC4=CC(F)=CC=C4)C)=O

• Molecular Formula :

  C22H26FN5O2

• Molecular Weight :

  411.47

• References & Citations :

  [1]Sun M, et al. Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115811. doi: 10.1016/j.bmc.2020.115811.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TrkA