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EGFR-IN-45

CAT: 0804-HY-145867Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145867Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 μM and 1.6 μM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].
CAS Number
2765560-03-8
UNSPSC
12352005
Target
Apoptosis; CDK; EGFR; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-45.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CC=CC=C2)=NC3=C1C(NC4=CC=CC=C43)=NC5=C(C)N(C)N(C6=CC=CC=C6)C5=O
Molecular Formula
C28H23N7O
Molecular Weight
473.53
References & Citations
[1]Mekheimer RA, Allam SMR, Al-Sheikh MA, et al. Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies. Bioorg Chem. 2022;121:105693.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; EGFR/ErbB1/HER1

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