HDAC-IN-32

• UNSPSC Description:

  HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac-in-32.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NO)CCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1

• Molecular Weight:

  353.41

• References & Citations:

  [1]"Chen C, et al. Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. J Med Chem. 2022 Feb 24;65(4):3667-3683. "

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2766688-17-7