DX3-235

• Description :

  DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity[1].

• CAS Number :

  [2749555-39-1]

• UNSPSC :

  12352005

• Target :

  Mitochondrial Metabolism; Oxidative Phosphorylation

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dx3-235.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C1=NOC(N2CCN(CC2)C([C@H]3CN(CCC3)S(=O)(C4=CC=C(C=C4)S(C(CC)CC)(=O)=O)=O)=O)=N1)C

• Molecular Formula :

  C26H39N5O6S2

• Molecular Weight :

  581.75

• References & Citations :

  [1]Xue D, et al. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors. J Med Chem. 2022;65 (1) :343-368.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported