DX3-235

• Description:

  DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity[1].

• UNSPSC:

  12352005

• Target:

  Mitochondrial Metabolism; Oxidative Phosphorylation

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dx3-235.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (C1=NOC (N2CCN (CC2) C ([C@H]3CN (CCC3) S (=O) (C4=CC=C (C=C4) S (C (CC) CC) (=O) =O) =O) =O) =N1) C

• Molecular Formula:

  C26H39N5O6S2

• Molecular Weight:

  581.75

• References & Citations:

  [1]Xue D, et al. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors. J Med Chem. 2022;65 (1) :343-368.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2749555-39-1