NGI-235

• Description:

  NGI-235 is a selective OST-A inhibitor that inhibits NF-κB inflammatory signaling by blocking TLR4 glycosylation[1].

• UNSPSC:

  12352100

• Target:

  NF-κB

• Related Pathways:

  NF-κB

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.11

• Smiles:

  O=C(C1=CC(S(=O)(N(CC2=CC=CC=C2)C)=O)=CC=C1N(CC3CC3)C)NC4=NC=C(CC)S4

• Molecular Formula:

  C25H30N4O3S2

• Molecular Weight:

  498.66

• References & Citations:

  [1]Lampson BL, et al. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024 Apr 25;187 (9) :2209-2223.e16.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2763063-40-5]