Anticancer agent 235
CAT:
804-HY-N13063
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anticancer agent 235
- CAS Number: 9007-83-4
- UNSPSC Description: Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1].
- Target Antigen: Akt; Apoptosis; PI3K; Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/anticancer-agent-235.html
- Smiles: CN1C2=NC3=CC(OC)=CC=C3C2=CC4=C1C=CC(Cl)=C4
- Molecular Weight: 296.75
- References & Citations: [1]Ma Y, et al. Synthesis and Biological Activity of 2-Chloro-8-methoxy-5-methyl-5 H-indolo [2, 3-b] Quinoline for the Treatment of Colorectal Cancer by Modulating PI3K/AKT/mTOR Pathways[J]. ACS Omega, 2024.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported