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GNE-235

CAT: 0804-HY-150289-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150289-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-235 is a compound selective for the second bromodomain of PBRM1, with a KD of 0.28 ± 0.02 μM. GNE-235 can be used for evaluation of the cellular function of PBRM1[1].
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-235.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H]1CCCN1C2=C(N)N=NC(C3=CC=CO3)=C2
Molecular Formula
C13H16N4O
Molecular Weight
244.29
References & Citations
[1]Cochran AG, et al. GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. J Med Chem. 2023 Sep 28;66 (18) :13116-13134.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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