NP3-146

• Description :

  NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056) /Nigericin (HY-127019) -stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases[1][2].

• Product Name Alternative :

  NLRP3-IN-5

• UNSPSC :

  12352005

• Target :

  Caspase; Interleukin Related; NOD-like Receptor (NLR)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/nlrp3-in-5.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C(C)C)C=C(Cl)C=C2C(C)C

• Molecular Formula :

  C20H27ClN2O5S

• Molecular Weight :

  442.96

• References & Citations :

  [1]Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 Dec 1;114:129987.|[2]Harrison D, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2022 Aug 1;13 (8) :1321-1328.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NLRP3

• CAS Number :

  [210826-47-4]