NP3-146

CAT: 0804-HY-145087Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-145087Size:1 Each
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Description
NP3-146 is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 shows potent inhibitory activity against IL-1β release with an IC50 value of 0.171 μM in LPS (HY-D1056) /Nigericin (HY-127019) -stimulated BMDM cells. NP3-146 regulates the levels of cleaved Caspase-1 and cleaved IL-1β in cell supernatants. NP3-146 can be used for the research of inflammatory diseases[1][2].
CAS Number
[210826-47-4]
Product Name Alternative
NLRP3-IN-5
UNSPSC
12352005
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=CC(C(C)(C)O)=CO1)=O)NC2=C(C(C)C)C=C(Cl)C=C2C(C)C
Molecular Formula
C20H27ClN2O5S
Molecular Weight
442.96
References & Citations
[1]Feng H, et al. Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors. Bioorg Med Chem Lett. 2024 Dec 1;114:129987.|[2]Harrison D, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2022 Aug 1;13 (8) :1321-1328.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

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