YT 146

• Description:

  YT 146 is a potent agonist of A2 adenosine receptor (A2 AR) agonist. YT 146 causes a concentreation dependent cAMP accumulation, with the EC50 of 1.5 nM. YT 146 has cardioprotective effects[1].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/yt-146.html

• Purity:

  99.72

• Smiles:

  O[C@@H]1[C@H] (O) [C@@H] (CO) O[C@H]1N2C3=NC (C#CCCCCCC) =NC (N) =C3N=C2

• Molecular Formula:

  C18H25N5O4

• Molecular Weight:

  375.42

• References & Citations:

  [1]Jun Sasamori, et al. Cardioprotective effects of 2-octynyladenosine (YT-146) in ischemic/reperfused rat hearts. J Cardiovasc Pharmacol. 2011 Feb;57 (2) :166-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Adenosine A2A receptor (A2AR)

• CAS Number:

  90596-75-1