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BSJ-04-146

CAT: 0804-HY-179512Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179512Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BSJ-04-146 is a highly efficient and selective PROTAC targeting focal adhesion kinase (FAK) (IC50 = 26 nM) . BSJ-04-146 achieves rapid and potent FAK degradation with high proteome-wide specificity in cancer cells and induces durable degradation in mice. BSJ-04-146 binds FAK and requires the ubiquitin-proteasome machinery to achieve FAK degradation. BSJ-04-146 can be used for the study of pancreatic cancer and triple-negative breast cancer[1].
CAS Number
2414478-45-6
UNSPSC
12352005
Target
FAK; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC(C)=C(C4CCN(CCCCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3OC(C)C)=NC=C2C(F)(F)F
Molecular Formula
C50H57F3N8O8
Molecular Weight
955.03
References & Citations
[1]Koide E, et al. Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity. Chembiochem. 2023 Oct 4;24 (19) :e202300141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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