NP3-253

• UNSPSC Description:

  NP3-253 is an NLRP3 inhibitor with oral activity and blood-brain barrier permeability, and NP3-253 can serve as a tool to further investigate the biological characteristics of NLRP3 in peripheral and neuroinflammatory model[1].

• Target Antigen:

  NOD-like Receptor (NLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/np3-253.html

• Smiles:

  CC1=CC(C(F)(F)F)=CC(O)=C1C2=NN=C(N[C@@H]3CCCN(CC)C3)C=C2

• Molecular Weight:

  380.41

• References & Citations:

  [1]Mackay A, et al. Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome[J]. Journal of Medicinal Chemistry, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2557349-50-3