NP3-253

• Description :

  NP3-253 is an NLRP3 inhibitor with oral activity and blood-brain barrier permeability, and NP3-253 can serve as a tool to further investigate the biological characteristics of NLRP3 in peripheral and neuroinflammatory model[1].

• UNSPSC :

  12352005

• Target :

  NOD-like Receptor (NLR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/np3-253.html

• Purity :

  99.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(C(F)(F)F)=CC(O)=C1C2=NN=C(N[C@@H]3CCCN(CC)C3)C=C2

• Molecular Formula :

  C19H23F3N4O

• Molecular Weight :

  380.41

• References & Citations :

  [1]Mackay A, et al. Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome[J]. Journal of Medicinal Chemistry, 2024.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2557349-50-3]