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NP3-253

CAT: 0804-HY-169996-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-169996-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NP3-253 is an NLRP3 inhibitor with oral activity and blood-brain barrier permeability, and NP3-253 can serve as a tool to further investigate the biological characteristics of NLRP3 in peripheral and neuroinflammatory model[1].
CAS Number
[2557349-50-3]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/np3-253.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C(F)(F)F)=CC(O)=C1C2=NN=C(N[C@@H]3CCCN(CC)C3)C=C2
Molecular Formula
C19H23F3N4O
Molecular Weight
380.41
References & Citations
[1]Mackay A, et al. Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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