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AChE-IN-12

CAT: 0804-HY-144790Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144790Size:1 Each
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Description
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 μM) . AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease[1].
CAS Number
2764664-52-8
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(O)C=C(OC)C(O)=C1OC)/C=C/C2=CC=C(OCCCCCCN(CC)CC3=CC=CC=C3OC)C=C2
Molecular Formula
C33H41NO7
Molecular Weight
563.68
References & Citations
[1]Sang Z, Song Q, Cao Z, Deng Y, Zhang L. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2022;37 (1) :69-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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