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AChE/BChE-IN-12

CAT: 0804-HY-149211Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149211Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research[1].
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-12.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(CN2C=C(N=N2)COC3=C(C4=C(C=C3)C=CC(O4)=O)C(C)=O)=CC(OC)=C1
Molecular Formula
C23H21N3O6
Molecular Weight
435.43
References & Citations
[1]Sharma A, et al. Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase. ACS Omega. 2023 Mar 16;8 (12) :11161-11176.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BACE1; BChE

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