FLT3-IN-14

FLT3-IN-14

• CAS Number: 2620551-45-1
• UNSPSC Description: FLT3-IN-14 is a potent FLT3 inhibitor with IC50s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model[1].
• Target Antigen: Apoptosis; FLT3
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-in-14.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)(C1=CC(NC(NC2=CC=C(C=C2)C3=CN4C5=C(SC4=N3)CCC6=CNC=C65)=O)=NO1)C
• Molecular Weight: 472.56
• References & Citations: [1]Cilibrasi V, Spanò V, Bortolozzi R, et al. Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations. Eur J Med Chem. 2022;235:114292.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported