FLT3-IN-11

FLT3-IN-11

• CAS Number: 2499966-50-4
• UNSPSC Description: FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase?inhibitor with IC50s of 7.22 nM and 4.95 nM for wild-type FLT3 and FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3 over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC50 of 3.2 nM)[1].
• Target Antigen: FLT3
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-in-11.html
• Solubility: 10 mM in DMSO
• Smiles: FC(F)(F)C(C(N[C@@H]1CC[C@@H](CC1)N)=N2)=CN=C2NC3=CC=C(C=C3)C(N(C)C)=O
• Molecular Weight: 422.45
• References & Citations: [1]Lexian Tong, et al. Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem. 2022 Feb 24;65(4):3229-3248.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported