FLT3-IN-13

FLT3-IN-13

• UNSPSC Description: FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC50 values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia[1].
• Target Antigen: Apoptosis; FLT3; Topoisomerase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-in-13.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(C(C(N/N=C/C3=CC=NC=C3)=O)=CC=C2)NC4=C1C=CC=C4
• Molecular Weight: 342.35
• References & Citations: [1]Abdelgawad MA, et al. Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorg Chem. 2022 May;122:105752.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported