FLT3-IN-25

• UNSPSC Description:

  FLT3-IN-25 (compound 17) is a potent inhibitor of FLT3, with IC50s of 1.2 nM, 1.4 nM and 1.1 nM for FLT3-WT, FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-25 plays an important role in acute myeloid leukemia (AML)[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-in-25.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@H]1O[C@@H](C)CN(C2=NN3C(C=C2)=NC=C3C4=CC=C(C5=CNN=C5)C=C4)C1

• Molecular Weight:

  374.44

• References & Citations:

  [1]Desmond Akwata, et al. Identification of a Selective FLT3 Inhibitor with Low Activity against VEGFR, FGFR, PDGFR, c-KIT, and RET Anti-Targets. ChemMedChem. 2023 Nov 16:e202300442.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported