FLT3-IN-25

FLT3-IN-25

• UNSPSC Description: FLT3-IN-25 (compound 17) is a potent inhibitor of FLT3, with IC50s of 1.2 nM, 1.4 nM and 1.1 nM for FLT3-WT, FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-25 plays an important role in acute myeloid leukemia (AML)[1].
• Target Antigen: FLT3
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-in-25.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H]1O[C@@H](C)CN(C2=NN3C(C=C2)=NC=C3C4=CC=C(C5=CNN=C5)C=C4)C1
• Molecular Weight: 374.44
• References & Citations: [1]Desmond Akwata, et al. Identification of a Selective FLT3 Inhibitor with Low Activity against VEGFR, FGFR, PDGFR, c-KIT, and RET Anti-Targets. ChemMedChem. 2023 Nov 16:e202300442.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported