FLT3-IN-21

• UNSPSC Description:

  FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC50: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC50: 5.3 nM). In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%)[1].

• Target Antigen:

  Apoptosis; FLT3

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-in-21.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(NC=C1NC(NN2CCCCC2)=O)/C=C(C3=CC(F)=CC=C3N4)\C4=O

• Molecular Weight:

  383.42

• References & Citations:

  [1]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645.|[2]Jin J, et al. Design, synthesis, and biological evaluation of a series of indolone derivatives as novel FLT3 inhibitors for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 Sep;138:106645..

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported