FLT3-IN-23

• UNSPSC Description:

  FLT3-IN-23 (compound 15) is an inhibitor of JFMS-like tyrosine kinase 3 (FLT3) with an IC50 of 7.42 nM. FLT3-IN-23 has antiproliferative activities against BaF3 cells carrying various FLT3-TKD and FLT3-ITD-TKD mutations[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-in-23.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1(COC1)COC2=CC=C(C=C2)NC3=NC=C(C(N[C@@H]4CC[C@H](N)CC4)=N3)C(F)(F)F

• Molecular Weight:

  451.49

• References & Citations:

  [1]Xuanmin Lian, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors. Bioorg Med Chem Lett. 2023, 23.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2489528-97-2