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FLT3-IN-12

CAT: 0931-T62412-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62412-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2499966-67-3
Target
Others, FLT
Related Pathways
Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM) . FLT3-IN-12 is more selective than c-KIT (>1000-fold) . FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.
Smiles
O=C1C=2C(=CC(NC=3N=C(N[C@@H]4CC[C@H](N)CC4)C(C(F)(F)F)=CN3)=CC2)C=CN1C
Molecular Formula
C21H23F3N6O
Molecular Weight
432.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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