ERRα antagonist-2

CAT: 0804-HY-144699-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144699-01Size:5 mg
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Description
ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC50 of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo[1].
CAS Number
[3032965-02-6]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/errα-antagonist-2.html
Purity
99.07
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)OC2=CC=CC=C2NS(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O
Molecular Formula
C19H16N2O6S
Molecular Weight
400.41
References & Citations
[1]Zhipei Gao, et al. The discovery of a novel series of potential ERRα inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :125-134.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRα

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