ERRα antagonist-2

• UNSPSC Description:

  ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC50 of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/errα-antagonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)OC2=CC=CC=C2NS(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O

• Molecular Weight:

  400.41

• References & Citations:

  [1]Zhipei Gao, et al. The discovery of a novel series of potential ERRα inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo. J Enzyme Inhib Med Chem. 2022 Dec;37(1):125-134.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032965-02-6