PROTAC ERRα ligand 2

• Description :

  PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Estrogen Receptor/ERR; Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/protac-err-alpha-ligand-2.html

• Purity :

  99.36

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=CC=C(C(F)(F)F)C=C2C(F)(F)F

• Molecular Formula :

  C20H13F6NO4

• Molecular Weight :

  445.31

• Precautions :

  H302

• References & Citations :

  [1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2306388-57-6]