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P2Y12 antagonist 2

CAT: 0804-HY-111755Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111755Size:1 Each
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Description
P2Y12 antagonist 2 is a potent P2Y12 receptor antagonist. P2Y12 antagonist 2 exhibits excellent antiplatelet aggregation potency with an IC50 value of 2.94 μM as well as antithrombotic efficacy in a rat ferric chloride model. P2Y12 antagonist 2 shows a superior safety profile than Clopidogrel in a rat tail-bleeding model. P2Y12 antagonist 2 can be used to research thromboembolic disorders[1].
CAS Number
2299200-91-0
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Oral_antiplatelet_agent_1.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1)C2=C1N=C(N3CCC(C(NS(CC4=CC=C(C)C=C4)(=O)=O)=O)(C)CC3)C(C#N)=C2
Molecular Formula
C23H24N4O5S
Molecular Weight
468.53
References & Citations
[1]Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6- (4- ((Benzylsulfonyl) carbamoyl) piperidin-1-yl) -5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62 (6) :3088-3106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y12 Receptor

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