ERRγ inverse agonist 2

ERRγ inverse agonist 2

• CAS Number: 324022-01-7
• UNSPSC Description: ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/errγ-inverse-agonist-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN(C2=CC=CC=C2)N=C1C3=CC=CC=C3)NC4=CC(N)=CC(OC5=CC=CN=C5)=C4
• Molecular Weight: 447.49
• References & Citations: [1]Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported