ERRγ inverse agonist 2

• Description :

  ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Infection; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/errγ-inverse-agonist-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CN(C2=CC=CC=C2)N=C1C3=CC=CC=C3)NC4=CC(N)=CC(OC5=CC=CN=C5)=C4

• Molecular Formula :

  C27H21N5O2

• Molecular Weight :

  447.49

• References & Citations :

  [1]Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERRγ

• CAS Number :

  [324022-01-7]