ERRγ inverse agonist 2

• UNSPSC Description:

  ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/errγ-inverse-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN(C2=CC=CC=C2)N=C1C3=CC=CC=C3)NC4=CC(N)=CC(OC5=CC=CN=C5)=C4

• Molecular Weight:

  447.49

• References & Citations:

  [1]Yang SH, et, al. Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists. Eur J Med Chem. 2023 Mar 15;250:115174.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  324022-01-7