LSD1-IN-13

CAT: 0804-HY-144675Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144675Size:1 Each
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Description
LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines[1].
CAS Number
[2170212-33-4]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-in-13.html
Solubility
10 mM in DMSO
Smiles
O=S(N1CCC2=C1C=CC([C@H]3[C@H](NCC4CCNCC4)C3)=C2)(C5=CC=CC=C5)=O
Molecular Formula
C23H29N3O2S
Molecular Weight
411.56
References & Citations
[1]Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4335-4349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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