LSD1-IN-15

• UNSPSC Description:

  LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC50 values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC50 of 9.9 μM[1].

• Target Antigen:

  Histone Demethylase; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-15.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1CC1C2=CC=C(C=C2)NC(C3=CC=CC(C4=CC=CC=C4)=C3)=O

• Molecular Weight:

  328.41

• References & Citations:

  [1]Fioravanti R, et al. Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity. J Enzyme Inhib Med Chem. 2022 Dec;37(1):973-985.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported