LSD1-IN-16

• Description:

  LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC50 values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC50 of 15.2 μM[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-16.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1CC1C2=CC=C (C=C2) NC (C3=CC=CC (C4=CC=CS4) =C3) =O

• Molecular Formula:

  C20H18N2OS

• Molecular Weight:

  334.43

• References & Citations:

  [1]Fioravanti R, et al. Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :973-985.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1; MAO-A; MAO-B