HbF inducer 2

• Description:

  HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM) . HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys[1].

• UNSPSC:

  12352005

• Target:

  Histone Acetyltransferase; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/hbf-inducer-2.html

• Concentration:

  10mM

• Purity:

  99.38

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C (N (CC1=C2C=CC (OC[C@@H]3N (CC) CCCC3) =C1) C2=O) CC4) NC4=O

• Molecular Formula:

  C21H27N3O4

• Molecular Weight:

  385.46

• References & Citations:

  [1]Ting PY, et al., A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Science. 2024 Jul 5;385 (6704) :91-99.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2654011-51-3