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ATR-IN-11

CAT: 0804-HY-144435Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144435Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS) . ATR-IN-11 is a promising lead compound for subsequent agent discovery targeting ATR kinase. ATR-IN-11 has the potential for the research of cancer disease[1].
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=NC(C3=CNC4=C3C=CC=C4)=NC(N5[C@@H](COCC5)C)=C2C1)C6CCNCC6
Molecular Formula
C25H30N6O2
Molecular Weight
446.54
References & Citations
[1]Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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