ATR-IN-11

ATR-IN-11

• UNSPSC Description: ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS). ATR-IN-11 is a promising lead compound for subsequent agent discovery targeting ATR kinase. ATR-IN-11 has the potential for the research of cancer disease[1].
• Target Antigen: ATM/ATR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/atr-in-11.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CC2=NC(C3=CNC4=C3C=CC=C4)=NC(N5[C@@H](COCC5)C)=C2C1)C6CCNCC6
• Molecular Weight: 446.54
• References & Citations: [1]Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported