Trk-IN-10

• CAS Number :

  2700265-61-6

• Target :

  Trk receptor|||Others

• Related Pathways :

  Others|||Tyrosine Kinase/Adaptors

• Bioactivity :

  Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk is a crucial drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, potentially reducing toxicity [1].

• Smiles :

  C[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC[C@H](C)OC=5C(C2)=CC=C(F)C5)OC1

• Molecular Formula :

  C20H20FN5O3

• Molecular Weight :

  397.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C