Trk-IN-10

• Target:

  Trk receptor|||Others

• Related Pathways:

  Others|||Tyrosine Kinase/Adaptors

• Bioactivity:

  Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk is a crucial drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, potentially reducing toxicity [1].

• Smiles:

  C[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC[C@H](C)OC=5C(C2)=CC=C(F)C5)OC1

• Molecular Formula:

  C20H20FN5O3

• Molecular Weight:

  397.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2700265-61-6