TNF-? Antagonist

• Target:

  TNF

• Related Pathways:

  Apoptosis

• Bioactivity:

  TNF-? antagonist is an exocyclic peptide that mimics the critical TNF-? recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-?B (RANK) and TNF-?'s recruitment and activation of osteoclasts. TNF-? antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

• Smiles:

  CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1

• Molecular Formula:

  C58H71N11O15S2

• Molecular Weight:

  1226.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  199999-60-5