TNF-? Antagonist

• Target:

  TNF

• Related Pathways:

  Apoptosis

• Bioactivity:

  TNF-? antagonist is an exocyclic peptide that mimics the critical TNF-? recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-?B (RANK) and TNF-?'s recruitment and activation of osteoclasts. TNF-? antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

• Smiles:

  CC (C) C[C@@H]1NC (=O) [C@H] (Cc2ccc (O) cc2) NC (=O) [C@H] (CCC (N) =O) NC (=O) [C@H] (CO) NC (=O) [C@H] (Cc2c[nH]c3ccccc23) NC (=O) [C@H] (CSSC[C@H] (NC1=O) C (=O) N[C@@H] (Cc1ccc (O) cc1) C (O) =O) NC (=O) [C@@H] (N) Cc1ccc (O) cc1

• Molecular Formula:

  C58H71N11O15S2

• Molecular Weight:

  1226.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  199999-60-5