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DHODH-IN-20

CAT: 0804-HY-144371Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144371Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHODH-IN-20 (Compound 133) is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia[1].
CAS Number
2639835-02-0
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dhodh-in-20.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1C)C2=CC(F)=C(C3=CN(C)C(C(C)(O)C)=N3)C=C2O[C@@H](C)C(F)(F)F
Molecular Formula
C24H25F4N3O3
Molecular Weight
479.47
References & Citations
[1]Sabnis RW. Biaryl Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML) . ACS Med Chem Lett. 2022;13 (2) :158-159.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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