DHODH-IN-4

• UNSPSC Description:

  DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].

• Target Antigen:

  Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dhodh-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1Cl)=O

• Molecular Weight:

  347.20

• References & Citations:

  [1]Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1148125-93-2